The story begins with Rob entering his bedroom, and attempting to masturbate with a peanut butter and jelly sandwich (similar to the apple pie scenario in the first film). While he is doing this his dog, Frizzie, tries to eat the sandwich, and Rob’s little brother Cody takes a video of him receiving this unwanted sexual gratification. Later, Rob meets with his friends, Nathan and Marshall Lube, at school. Nathan reveals that his girlfriend, Dana, has pledged to abstain from sex until marriage despite the fact that she has already slept with six other people. Rob talks to Heidi, a girl he is attracted to, and Stifler. Stifler states that if Rob doesn’t make a move on Heidi, he will. In class, Lube has a vivid fantasy about a group of cheerleaders, particularly one named Ashley. Rob and Heidi meet later in the school library where she discloses that she is a virgin, and wishes to just “get it [sex] over with”. At the school dance, Nathan tries to get to second base with Dana, but only manages to offend her due to her abstinence pledge. Rob attempts to tell Heidi how he feels about her but is interrupted by Nathan and Lube. He eventually finds her in the library about to have sex with another student, and drops a lit candle in a bin in shock. This sets the library on fire, which sets off the water sprinklers.
The next day, when Rob and Heidi are cleaning the library, Rob finds a secret compartment containing ‘The Bible’ (The Book of Love). He shows the book to his friends Nathan and Lube and explains that it is a sex manual that has been compiled over forty years by the students who found it. The book is regarded as legendary, but unfortunately has been damaged by the water.
Later in the local mall, Rob attempts to test a tip in the book; ‘Simple Flattery’. He approaches Ashley in a lingerie store and complements her. Ashley leads him into a changing room, takes off her bra and top, and makes him steal a bra for her. Unfortunately Rob is caught and forced to pay for the bra with his mom’s credit card. Meanwhile, Nathan goes to Dana’s church service to talk to her, but accidentally broadcasts the explicit and highly personal conversation to the entire congregation on the church’s PA system. Dana’s father then bans Dana from seeing Nathan. When she receives her credit card bill, Rob’s mom tries to talk to him about buying underwear, prompting Rob to sarcastically say that he likes wearing women’s underwear. He is again filmed by his little brother, who again posts the footage on the internet for the whole school to see.
The next day, Heidi, Imogen, and Dana are spectating at a school basketball game in which Rob and Stifler are playing. A girl called Katie tries to talk to Stifler, but he brushes her off. Rob again attempts to tell Heidi how he feels, but is unable to. Lube discovers a page in The Bible which tells of a brothel in Canada and a prostitute, Monique, who is very experienced. The entry was written in 1975, but Lube misreads the date as 1995, and they decide to visit. When they meet Monique the boys are disgusted, but Nathan states that they should go for it anyway. Nathan and Lube make Rob go first, but Monique dies while performing oral sex on him. They panic and drive back to the USA.