Reggie the turkey has always been afraid of Thanksgiving because turkeys have always been on the menu, but his attempts to warn his farm-based flock constantly fall on deaf ears and has made him an outcast. When the other turkeys finally realize what is going on, they throw Reggie outside in an attempt to save themselves. In a surprise twist of fate, he winds up being named the “pardoned turkey” by the President of the United States and is subsequently taken to Camp David. Although initially hesitant, Reggie soon eases into a routine of doing nothing but enjoying pizza delivered to him by the “Pizza Dude” and watching Mexican telenovelas.
He gets bag-kidnapped by Jake, a member of the Turkey Freedom Front who tells him that a “Great Turkey” told him to find Reggie and take him back to the first Thanksgiving with him to take turkeys off the menu once and for all. They then infiltrate the base where a time machine is located. Despite interference by federal officials and an attempt by Reggie to trick him back to the surface, Jake manages to commandeer an egg-shaped time machine with an A.I. software named S.T.E.V.E (Space Time Exploration Vehicle Envoy). Jake instructs S.T.E.V.E. to time-travel back to the same day in 1621, three days before the first Thanksgiving. Once there, they are ambushed by colonial hunters led by Myles Standish, but they are quickly rescued by native turkeys led by Chief Broadbeak and his two children, Ranger and Jenny.
Broadbeak explains that the turkeys in the area have been forced underground since the settlers came and that they cannot risk fighting back without the settlers taking them. The next day, Broadbeak orders Jake with Ranger to spy on the settlers and Reggie with Jenny to spring all the hunting traps the humans set up. Despite initial hostility, Ranger and Jake find out that the settlers have already begun preparations for Thanksgiving and where they keep their weapons. Meanwhile, Jenny believes in Reggie for lying about being from the future and is impressed with his accidental unorthodox way of springing the traps. However, they are soon intercepted by Standish and Reggie is forced to get her in orbit over the planet aboard S.T.E.V.E., validating everything he said in the process. Reggie asks Jenny to go back to the future with him once everything blows over, but she refuses to leave the flock no matter how much she likes him. Jake then drags Reggie away and tells him he has a plan to attack the settlers. However, Reggie has gotten sick of all his improbable stories and threatens to leave.