After defeating Owen Shaw and his crew and securing amnesty for their past crimes, Dominic “Dom” Toretto, Brian O’Conner and the rest of their team have returned to the United States to live normal lives again. Brian begins to accustom himself to life as a father, while Dom tries to help Letty Ortiz regain her memory. Meanwhile, Owen’s older brother, Deckard Shaw, breaks into the secure hospital the comatose Owen is being held in and swears vengeance against Dom, before breaking into Luke Hobbs’ DSS office to extract profiles of Dom’s crew. After revealing his identity, Shaw engages Hobbs in a fight, and escapes when he detonates a bomb that severely injures Hobbs. Dom later learns from his sister Mia that she is pregnant again and convinces her to tell Brian. However, a bomb, disguised in a package sent from Tokyo, explodes and destroys the Toretto house just seconds after Han, a member of Dom’s team, is killed by Shaw in Tokyo. Dom later visits Hobbs in a hospital, where he learns that Shaw is a rogue special forces assassin seeking to avenge his brother. Dom then travels to Tokyo to claim Han’s body, and meets and races Sean Boswell, a friend of Han’s who gives him personal items found at Han’s crash site.
Back at Han’s funeral in Los Angeles, Dom notices a car observing them, and after a chase, confronts its driver, who is revealed to be Shaw. Both prepare to fight, but Shaw flees when a covert ops team arrives and opens fire. The team is led by a man who calls himself Mr. Nobody, who says that he will assist Dom in stopping Shaw if he helps him obtain the God’s Eye, a computer program that uses digital devices to track down a person, and save its creator, a hacker named Ramsey, from a mercenary named Mose Jakande. Dom, Brian, Letty, Roman Pearce, and Tej Parker then airdrop their cars over the Caucasus Mountains in Azerbaijan, ambush Jakande’s convoy, and rescue Ramsey. The team then heads to Abu Dhabi, where a billionaire has acquired the flash drive containing the God’s Eye, and manages to steal it from the owner. With the God’s Eye near telecommunications repeaters, the team tracks down Shaw, who is waiting at a remote factory. Dom, Brian, Mr. Nobody and his team attempt to capture Shaw, but are ambushed by Jakande and his men, and are forced to flee while Jakande obtains the God’s Eye. At his own request, the injured Mr. Nobody is then left behind to be evacuated by helicopter while Brian and Dom continue without him. Left with no other choice, the crew returns to Los Angeles to fight Shaw, Jakande, and his men. Meanwhile, Brian promises Mia that once they deal with Shaw, he will dedicate himself entirely to their family.