The film opens with a shuriken (flying star) flying through the air and hitting a wooden post, as a man runs for his life. When the man reaches the road, the Creeper suddenly drops from the sky and flies off with him while another man watches from his truck. When he gets out to investigate, he looks up in the air and sees a severed hand fall from the sky.
Twenty-three years later, shortly after the events of the first film, the police discover the Creeper’s truck filled with dead bodies. The truck has been rigged with several booby-traps, including spikes that emerge from the back, and a spear that shoots out from the tail-pipe. When Sheriff Dan Tashtego arrives, Sergeant Davis Tubbs tells him what happened and Tashtego informs him that the Creeper has been around for thousands of years and must be stopped. They then rush to get the Creeper’s truck back after learning it is headed for the impound. As Frank and Deputy Lang transport the vehicle, the Creeper lands on the tow truck and severs the cables. They then watch as the truck drives off seemingly on its own, while the Creeper stands on top of it. When the truck turns around, the Creeper lands on Frank and abducts him while Lang froze in fear, pointing her gun at it. The next day, Gaylen Brandon sees a vision of her son Kenny, who was killed by the Creeper twenty-three years earlier. He warns her that the Creeper will return soon to uncover something buried on the property and will kill anyone there, including her and her granddaughter, Addison.
Meanwhile, Tashtego informs Tubbs that he has put together a small team to hunt down the Creeper and kill it once and for all. Later, a group of teenagers discovers the Creeper’s truck in a field. After finding the bodies, they take off on dirt bikes but one of them, Kirk, is shot in the leg with the spear. As two of the other boys try to free him, the Creeper returns and kills them both with another spear. The last boy is abducted by the Creeper as he tries to escape for peeing on the Creeper’s truck. Later, Addison goes into town to buy hay for her horse. When she can’t pay for it, her friend Buddy helps her out and the two drive up to a plantation house to deliver more hay. There they find the owner and a couple other men hiding under cars, but before they can get help the Creeper arrives and abducts Addison, leaving Buddy traumatized. Gaylen discovers a sack containing the Creeper’s severed hand buried in her front yard, and when she touches it she goes into a hypnotic state. When Tashtego and Tubbs arrive with the team, she reveals that the hand contains secrets about the Creeper’s origins, and Tashtego decides to touch it to uncover a possible way to kill it. Addison wakes up in the Creeper’s truck, along with Kirk and together they try to find a way out. When Kirk reaches for the door handle a spear shoots out from between the seats and impales him in the head.