In the year 2029, mutants are on the brink of extinction, with no new mutants having been born in 25 years. James “Logan” Howlett, formerly known as Wolverine, spends his days working as a chauffeur in Texas. His healing factor has faltered and, as a result, his body has aged greatly and his adamantium skeleton is poisoning him. Logan lives with mutant tracker Caliban in an abandoned smelting plant across the Mexican border, where they care for Professor Charles Xavier, who is suffering from Alzheimer’s disease which causes him to lose control of his telepathic abilities to destructive effect. One day, Logan is approached by Gabriela Lopez, a nurse for biotechnology corporation Alkali-Transigen, who wants him to escort her and an 11-year-old girl named Laura to a place in North Dakota called “Eden”.
After reluctantly accepting the job from Gabriela, Logan discovers that she has been murdered. He, Xavier, and Laura narrowly escape from her killer, Transigen’s cybernetically-enhanced chief of security Donald Pierce, and his enforcers, the Reavers, but Caliban is captured and forced to use his powers to track them. Logan and Xavier learn that Laura is one of several mutant children Transigen was breeding using DNA samples from several mutants for the “X-23” project, and that upon completion of the “X-24” project, the children were deemed obsolete and were to be euthanized. Gabriela helped several children escape from the Transigen compound before smuggling Laura, who is revealed to have been created from Logan’s DNA, across the border.
The Reavers catch up with them in Oklahoma City, but Xavier suffers a seizure and telepathically freezes everyone in their hotel, allowing Logan to kill the attackers before injecting Xavier with a suppressant and escaping. While on the highway, the trio helps farmer Will Munson and his family after a traffic incident. The Munsons invite them over for dinner, and they accept under the guise of being a trigenerational family. When a nearby pipe springs a leak, Logan and Will leave the house to fix it.