Luck is the story of gambling kingpin Karim Musa (Sanjay Dutt), who is a very lucky person seeing the story of his life. He remained the sole survivor when a mosque collapsed in Maharashtra when he was just a child of nine months and was amongst very few survivors of another incident at the age of 12. When he was 14, he challenged three friends to jump from a four-storied building and remained alive, though with some injuries, and won. He started gambling at 19 and since then tried out his luck in different places of the world and became known as Musa Bhai. To him gambling and drug smuggling have become old ways to get money, his latest interest is investment on people’s luck.
Later, along with Ram, Tamang hires (Mithun Chakrabarty), who is a soldier as lucky one as he fought inTamang battles and faced numerous bullets none that could kill him. He is in need of money for the operation of his wife Sheila (Roopa Ganguly). Tamang then visits Pakistan where Shortcut (Chitrashi Rawat), a 16-year-old girl, who is also known to be lucky as any camel she rides wins the race and observes her winning one despite her camel’s half-broken leg. Tamang pays four lakh rupees to “export” her to South Africa. Tamang then invites the sole-criminal, Raghav Raghuvaran (Ravi Kishan) to the game. Raghav was put in Tihar Jail for raping many women, and also killing them, but when he was hanged, he survived, and since the Indian law doesn’t allow one person to be hanged twice, he frees from Tihar Jail.
All competitors arrive in Cape Town. There, Ram meets a girl (Shruti Haasan). Her name is revealed to be Ayesha and Tamang says she took part in the game once before. In their first game, all competitors shoot the person to their right at the same time. All the unlucky ones die, though the lucky ones survive. Later that night, while everyone is eating at a dining table, Raghav goes to Ayesha’s room, and starts flirting with her, though Ayesha pays no attention and leaves. The second game is where all of the investments take parachutes and jump off from a helicopter.Some parachutes open while others don’t. Among the unlucky is Ayesha whose parachute doesn’t open but she is saved by Ram, who developed a liking towards her, and afterwards, they start getting closer. In the third game, everyone is left in a hollow tank with one of everyone’s hand locked with handcuffs and in front of them are 300 keys and one each will open the handcuffs and added to their trouble are the sharks that swim around them as they start opening the handcuffs as the tank sinks. Only one dies,but Shortcut is attacked by a shark. The shark bites her leg, but since Ram can’t bear to see it, he jumps into the water, and saves the harmed Shortcut (who is then taken to the hospital). Later on, it is revealed that due to her leg, Shortcut will not be taking part in any of the games any more.