Following a nuclear holocaust, the world has become a desert wasteland and civilization has collapsed. Max Rockatansky, a survivor, is captured by the War Boys, the army of the tyrannical Immortan Joe, and taken to Joe’s Citadel. Designated a universal blood donor, Max is imprisoned and used as a “blood bag” for a sick War Boy called Nux. Meanwhile, Imperator Furiosa, one of Joe’s lieutenants, is sent in her armoured semi-truck, the “War Rig”, to collect gasoline. When she drives off-route, Joe realizes that his five wives—women selected for breeding—are missing. Joe leads his entire army in pursuit of Furiosa, calling on the aid of nearby Gas Town and the Bullet Farm.
Nux joins the pursuit with Max strapped to his car to continue supplying blood. A battle ensues between the War Rig and Joe’s forces. Furiosa drives into a sand storm, evading her pursuers, except Nux, who attempts to sacrifice himself to destroy the Rig. Max escapes and restrains Nux, but the car is destroyed. After the storm, Max sees Furiosa repairing the Rig, accompanied by the wives: Capable, Cheedo, Toast, the Dag and the Splendid Angharad, who is heavily pregnant with Joe’s child. Max steals the Rig, but its kill switch disables it. Max reluctantly agrees to let Furiosa and the wives accompany him; Nux, left behind, is picked up by Joe’s army.
Furiosa drives through a biker gang-controlled canyon to barter a deal for safe passage; however, with Joe’s forces pursuing, the gang turns on her, forcing her and the group to flee while the bikers detonate the canyon walls to block Joe. Max and Furiosa fight pursuing bikers as Joe’s car, with Nux now on board, surmounts the blockade and eventually attacks the War Rig, allowing Nux to board. However, as the Rig escapes, Angharad falls off in an attempt to protect Max and is run over by Joe’s car, killing her and her child.
Furiosa explains to Max that they are escaping to the “Green Place”, an idyllic land she remembers from her childhood. Capable finds Nux hiding in the Rig, distraught over his failure, and consoles him. That night, the Rig gets stuck in mud. Furiosa and Max slow Joe’s forces with mines, but Joe’s ally, the Bullet Farmer, continues pursuing them. Nux helps Max free the Rig while Furiosa shoots and blinds the Bullet Farmer. Max walks into the dark to confront the Bullet Farmer and his men, returning with guns and ammunition.
They drive the War Rig overnight through swampland and desert, coming across a naked woman the next day. Max suspects a trap, but Furiosa approaches the woman and states her history and clan affiliation. The naked woman summons her clan, the Vuvalini, who recognize Furiosa as one of their own who was kidnapped as a child. Furiosa is devastated to learn that the swampland they passed was indeed the Green Place, now uninhabitable. The group then plans to ride motorbikes across immense salt flats in the hope of finding a new home. Max chooses to stay behind, but after seeing visions of a child he failed to save, he convinces them to return to the undefended Citadel, which has ample water and greenery that Joe keeps for himself, and trap Joe and his army in the bikers’ canyon.
The group heads back to the Citadel, but they are attacked en route by Joe’s forces, and Furiosa is seriously wounded. Joe positions his car in front of the War Rig to slow it, while Max fights Joe’s giant son, Rictus Erectus. Joe captures Toast, who manages to distract him long enough for Furiosa to kill him. Nux sacrifices himself by wrecking the Rig, killing Rictus and blocking the canyon, allowing Max, Furiosa, the wives, and the surviving Vuvalini to escape in Joe’s car, where Max transfuses his blood to Furiosa, saving her life.
At the Citadel, the impoverished citizens react to Joe’s death with joy. Furiosa, the wives, and the Vuvalini are cheered by the people and welcomed by the remaining War Boys. Max shares a respectful glance with Furiosa before blending into the crowd and again departing for parts unknown.