Royce awakens to find himself parachuting into an unfamiliar jungle. He meets several others who arrived in the same manner: Mexican drug cartel enforcer Cuchillo, Spetsnaz soldier Nikolai, Israel Defense Forces sniper Isabelle, Revolutionary United Front officer Mombasa, San Quentin death row inmate Stans, Yakuza enforcer Hanzo and general practice doctor Edwin.
Upon landing, they discover that all are armed and lethal killers, with the apparent exception of Edwin, though none know where they are or how they got there. The group follows Royce, who Isabelle suspects is a former black operations soldier turned mercenary. In the jungle they find empty cages, plants with a neurotoxic poison that Edwin collects on a scalpel, and a deceased US Special Forces soldier. Arriving at higher ground, they find themselves staring at an alien sky and realize that they are not on Earth.
The party is attacked by a pack of quadruped alien beasts. Cuchillo is killed, and his body is then used as bait to lure the survivors into a trap, but they avoid it. Royce deduces they are on a planet used as a game preserve, where humans are hunted as game. The group follows the quadrupeds’ tracks to a camp and finds a captive Predator. The “hunters”, three larger Predators, attack the group. Mombasa is killed and the rest of the group escapes. Royce confronts Isabelle, believing she knows something about the creatures based on her shock of recognition when they encountered the alien. She reveals that she has heard of the Predators before, from a report by the only survivor (Major Alan “Dutch” Schaefer) of a Special Forces team who encountered one twenty three years earlier in Guatemala.
The group next meets Noland, a lone soldier who has survived on the planet for “ten seasons” by hiding and scavenging from the Predators and their victims. At his hideout, he explains that the Predators sharpen their killing skills by collecting warriors and dangerous beasts from other worlds and bringing them to the planet to hunt. Noland also reveals that there is a blood feud between the larger Predators and the smaller ones. Royce hopes that if the group can free the smaller Predator being held prisoner in the encampment, it may take them home using the other Predators’ spaceship.