Tees Maar Khan mainly revolves around conman Tabrez Khan (Akshay Kumar) who has been a criminal since he was young. He was caught in France and deported back to India. Two police officers Chatterjee (Aman Verma) and Mukherjee (Murli Sharma) escorted him but he escaped.
His wife is struggling actress Anya Khan (Katrina Kaif). Tabrez takes a job from the Johri brothers (Raghu Ram and Rajiv Laxman) to rob a non-stop train loaded with precious antiques. He cons the people of Dhulia village into helping him by saying that he will make a historical film about their village. He approaches the greedy but popular actor Aatish Kapoor (Akshaye Khanna), who is eager to get the Oscar award and fools him into working in his “film”. While shooting in the village Tabrez gets the news that train will reach the village side after a week and hence shortage of the equipments for resume shooting occurs. To overcome this problem the group plans to rob the bank and buy the equipments, but people of dhulia comes to know about financial problem of Tabrez and decides to help him. While they are following Tabrez to help him he misunstands that they know about their robbery and true identity and are willing to expose him and giving him to police. Accidentally Tabrez runs into the forest exposing a child abduction ring and thus helping many villagers find their long-lost children, after knowing the intention of the villagers Tabrez feels guilty about conning the villagers and swears that he will give them a share of the treasure. The robbery goes well but he and all the villagers get arrested while the Johri brothers make off with the treasure. Tabrez claims that he is innocent, but gets imprisoned.