As the Smurfs get ready for the Blue Moon Festival, Papa Smurf sees in his cauldron a vision of Clumsy Smurf reaching for a dragon wand and the Smurfs in cages while Gargamel laughs. Not wanting this vision to come true, Papa Smurf disallows Clumsy to pick Smurf Roots. Clumsy disobeys Papa and ends up unintentionally leading Gargamel and Azrael to the village. The Smurfs all flee for their lives while Clumsy unknowingly runs towards the Forbidden Falls, with Papa Smurf, Smurfette, Grouchy, Brainy and Gutsy running after him. They find him at the edge of a cliff, and while trying to help him up, they are sucked into a gigantic vortex that spirits them to present day New York City. To make matters worse, Gargamel and Azrael follow and the Smurfs end up in the apartment of Patrick and Grace Winslow, a married and expectant couple and their Basset Hound Elway. After clarifying things, the Winslows befriend them and allow them to stay in their apartment. The next day, needing to find a “star gazer” (a telescope), the Smurfs follow Patrick to his workplace at Anjelou Cosmetics, misunderstanding the previous explanation of his job as fortune-telling. He calls Grace to pick them up.
However, having extracted “Smurf essence” from a lock of Smurfette’s hair, Gargamel also arrives and ends up being treated by Patrick’s boss Odile upon using most of his acquired magic on her elderly mother by restoring her youth and attractiveness. But Gargamel resumes his search upon recognizing Patrick and following him to FAO Schwarz but gets arrested after stealing a leaf blower and for causing chaos in the store with some customers while trying to catch the Smurfs. Gargamel manages to bust out of jail with the aid of flies. By that time, Papa Smurf manages to calculate the night he and the others can get home. But first, he must figure out the spell to do so. Patrick tells them that there is an old bookstore in the city near Anjelou Cosmetics as he bonds with the Smurfs after sending what he believed to be his finished advertisement to be published. However, the next day, Patrick learns that Clumsy accidentally attached a blue-moon themed side project and he loses his temper before walking out on both the Smurfs and Grace to save his job.