In 1977, the children at the Sisters of Mercy Orphanage are playing soccer with an old soda can in the front yard. But then, Sister Mary-Mengele (Larry David), the meanest nun in the orphanage gets their attention by telling them to go inside and do their work. The kids sing “Everybody is Special”, but she tells them to shut up and go to work. Later, Moe, Larry and Curly are dumped on the doorstep of the orphanage as babies. Ever since, the trio have wreaked havoc in the place, leaving the nuns who run it utterly terrified, especially Sister Mary-Mengele who has always hated the trio. Ten years later, in 1987, out of desperation, when a prospective couple comes to adopt, the exasperated nuns bring out the trio as being the only three available, eventually adding a fourth when another boy, Teddy, enters the picture. The couple, the Harters (Stephen Collins and Carly Craig), decides to pick Moe, but when he requests Larry and Curly to join him, he is dropped back off at the orphanage, and they choose Teddy instead.
25 years later in 2012, the trio (Chris Diamantopoulos, Sean Hayes and Will Sasso) are adults and are still living at the orphanage and working as janitors. Monsignor Ratliffe (Brian Doyle-Murray) arrives to give everyone an important message. After Monsignor Ratliffe tells Mother Superior (Jane Lynch) that the orphanage is going to close, she tells Sister Mary-Mengele to get the trio. Sister Mary-Mengele demands Mother Superior tell them who’s responsible for the foreclosure of the orphanage, but Mother Superior tells her to just tell them what they need to hear. However, the three stooges injure Sister Mary-Mengele. They head to Mother Superior until they cause Monsignor Ratliffe to fall on top of the nuns. Monsignor Ratliffe gets attacked by Moe, Larry and Curly, who think that Monsignor Ratliffe was making out with the nuns. Monsignor Ratliffe is not going to adopt any of them either, as he is on official business. Curly says “Official business?! Why didn’t you say so?” and they take off their blue worksuit revealing their shirts and shorts and present themselves to be adopted. When they are informed that the orphanage will be shutting down unless they can come up with $830,000 in 30 days, the trio volunteers to go out and try to raise the money somehow. Sister Rosemary (Jennifer Hudson) and the Stooges sing “This Little Light of Mine”, but Sister Mary-Mengele tells them to shut up and tells them it is only an orphanage, not a revival. Some of the nuns think that the trio will not be able to succeed because the only people they know are nuns and kids, but Mother Superior thinks otherwise.