At Fashion Interpol, Valentina Valencia examines the expressions of recently assassinated pop singers’ last images and believes they match Derek Zoolander’s trademark look, “Blue Steel”. A flashback reveals that the Derek Zoolander Center For Kids Who Can’t Read Good collapsed, killing Matilda Jeffries and injuring Hansel McDonald. Derek later lost custody of his son, Derek Zoolander Jr., and announced his retirement from modeling and subsequent reclusion.
Derek now lives alone in “extreme northern” New Jersey. Billy Zane visits and gives him an invitation to the House of Atoz fashion show by Alexanya Atoz, and persuades him to return to a regular lifestyle in order to regain custody of his son. In the “uncharted Malibu territories”, Hansel returns to his home after dinner and is informed by his orgy that they are all pregnant and that he is the father. He is later given the same invitation by Zane. After reuniting, Derek and Hansel are tracked down by Valentina, who asks them to help Interpol uncover who is behind the systematic assassinations.
At the fashion show, Derek and Hansel are surprised to find that the ever-changing fashion world is now dominated by the likes of Don Atari and the non-binary gendered All. They are put on the runway in “Old” and “Lame” outfits and are doused by a large bucket of prunes. Afterwards, Alexanya congratulates them on their performance.